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KMID : 0377619730240050513
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Korean Jungang Medical Journal
1973 Volume.24 No. 5 p.513 ~ p.516
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Influence of Ginseng Upon Cerebellar Nucleic Acid Contents of Mice
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Abstract
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As a part of efforts to elucidate the influence of Panax Ginseng upon nucleic acid content of various tissues, a study was carried out which measured cerebellar contents of RNA and DNA following administration of ginseng. Twenty male mice (body weight: 18-20 gm) were equally divided into a ginseng and a saline group. Once a day for 5 days they received subcutaneously 0.05 ml/10 gm body weight of ginseng ?extract solution (4 mg of ginseng alcohol extract in 1 ml of saline), and the same amount of saline, respectively. On the 5th experimental day, all animals were sacrificed 2 hours after the last medication and their cerebellar tissue was removed. Cerebellar RNA and DNA contents were measured using the chemical method of Schmidt-Thannhauser-Schneder.
Results obtained were as follows:
1. Cerebellar RNA and DNA contents were significantly higher in the ginseng group than in the saline group.
2. RNA/DNA ratio of the cerebellar tissue was much lower in the ginseng group than in the saline group due to a more remarkable increase in DNA than in RNA content following administration of ginseng.
The ginseng is, inferred to augment RNA and, especially, DNA contents of cerebellar tissue in mice.
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